10 Differences Between wellbutrin xl and sr

What is Wellbutrin XL?

Wellbutrin XL, also known as bupropion XL, is a prescription medication commonly used to treat depression, seasonal affective disorder (SAD), and to help individuals quit smoking. It belongs to a class of drugs called antidepressants, specifically aminoketones. Wellbutrin XL works by increasing certain neurotransmitters in the brain, such as dopamine and norepinephrine, which are associated with mood and motivation.

Examples of Wellbutrin XL:

  • Brand name: Wellbutrin XL
  • Generic name: Bupropion XL

Uses of Wellbutrin XL:

Wellbutrin XL is primarily prescribed for the following conditions:

  • Major depressive disorder
  • Seasonal affective disorder (SAD)
  • Smoking cessation

What is SR?

SR stands for sustained release, which refers to the formulation of medication that is released slowly into the body over a specified period. In the case of Wellbutrin SR, it is another formulation of bupropion, but with a different release mechanism compared to Wellbutrin XL. Wellbutrin SR is primarily used for the same conditions as Wellbutrin XL.

Examples of SR:

  • Brand name: Wellbutrin SR
  • Generic name: Bupropion SR

Uses of SR:

The uses of Wellbutrin SR are similar to those of Wellbutrin XL:

  • Major depressive disorder
  • Seasonal affective disorder (SAD)
  • Smoking cessation

Differences between Wellbutrin XL and SR:

Difference Area Wellbutrin XL Wellbutrin SR
Formulation Extended-release Sustained-release
Dosing Frequency Once daily Twice daily
Maximum Daily Dose 450 mg 400 mg
Half-life 20-37 hours 14 hours
Onset of Action Gradual Gradual
Duration of Action 24 hours Approximately 16 hours
Prescription Requirements Patient requires brand name prescription Generic substitution is allowed
Available Strengths 150 mg, 300 mg 100 mg, 150 mg, 200 mg
Recommended Starting Dose 150 mg once daily 100 mg twice daily
Suitability for Smokers Possible choice for smokers who want to quit Possible choice for smokers who want to quit


In summary, both Wellbutrin XL and SR are formulations of the antidepressant bupropion and are commonly used for the treatment of major depressive disorder, seasonal affective disorder, and smoking cessation. The main differences lie in their release mechanisms, dosing frequency, and maximum daily doses.

People Also Ask:

Here are some common questions about Wellbutrin XL and SR:

Q: Can Wellbutrin XL and SR be used interchangeably?

A: Wellbutrin XL and SR have different release mechanisms, but both contain the active ingredient bupropion. While they are generally used for the same indications, it is important to follow your doctor’s instructions and not substitute one for the other without consulting a healthcare professional.

Q: How long does it take for Wellbutrin XL and SR to start working?

A: The onset of action for both Wellbutrin XL and SR is gradual. It may take several weeks of consistent use to experience the full therapeutic effects. It is important to continue taking the medication as prescribed by your doctor, even if you do not notice immediate improvements.

Q: Is Wellbutrin XL or SR better for smoking cessation?

A: Both Wellbutrin XL and SR have been shown to be effective for smoking cessation. They work by reducing cravings and withdrawal symptoms associated with nicotine dependence. Your healthcare provider can help determine which formulation is most suitable for you based on your specific needs and medical history.

Q: Are there any significant side effects associated with Wellbutrin XL and SR?

A: Common side effects of Wellbutrin XL and SR can include headaches, nausea, insomnia, weight loss, and dry mouth. However, everyone may react differently to these medications, and there can be more serious side effects. It is important to discuss any concerns or potential side effects with your doctor.

Q: Can Wellbutrin XL or SR cause weight gain?

A: Weight loss is a potential side effect of both Wellbutrin XL and SR. However, individual responses may vary, and some individuals may experience weight gain while taking these medications. If weight changes are a concern, it is recommended to discuss this with your doctor to explore possible strategies or alternative treatments.

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